Abstract
The association between miR-423 polymorphism (C > A) and the risk of different cancers are still controversial. We performed a meta-analysis to clarify its association with multiple cancer risks. PubMed and Embase (as of 10th September, 2016) were searched. A total of 17 studies from 16 articles, consisting of 8,582 cases and 10,291 controls, were finally qualified and enrolled in this meta-analysis. The pooled results showed that the miR-423 AA genotype was associated with decreased cancer risk under the recessive model (odds ratio [OR] = 0.87, 95% confidence interval [CI]: 0.78~0.98, P = 0.020). However, this association became non-significant after excluding the study with the smallest odds ratio. Subgroup analyses revealed a significant decrease in risk of lung cancer (dominant model: OR = 0.73, 95 % CI: 0.60~0.89, P = 0.002; recessive model: OR = 0.59, 95 % CI: 0.37~0.95, P = 0.031). Our study indicates that miR-423 rs6505162 might be associated with a reduced risk of cancers, however, this finding need to be evaluated further in larger samples, especially subgroup analyses. In addition, cancer-specific functional studies are especially needed to reveal the underlying mechanisms between miR-423 and the etiology of cancer.
Highlights
Cancer poses a major threat to public health worldwide, and its burden continues to increase [1]
MicroRNAs are a class of endogenous, non-coding, single-stranded RNAs approximately 22 nucleotides in length. microRNAs guide RNA-induced silencing complex to the miRNA recognition elements of the targeted protein-coding transcripts or other competitive endogenous RNAs, and thereby play a role in post-transcriptional regulation [3,4,5,6].The target genes cover about one-third of the human genome, including genes involved in cell division, growth, differentiation, proliferation and apoptosis [7]
HardyWeinberg equilibrium (HWE) tests were performed in all but one study, [29] and the genotyping distribution was in agreement with HWE in these studies
Summary
Cancer poses a major threat to public health worldwide, and its burden continues to increase [1]. It is reasonable that single-nucleotide polymorphisms (SNPs) in miRNAs genes might alter miRNAs expression and maturation. These SNPs can alter the effects of miRNAs on their target genes, possibly leading to abnormal biological metabolism and modified cancer susceptibility [8, 11, 12]. A growing number of studies have been conducted to assess this polymorphism’s association with the risk of different cancers, but the results are conflicting rather than conclusive [18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33]. Given the requirement of risk classification in populations, [34] we performed this systematic review and meta-analysis to improve evaluation of the association between miR-423 rs6505162 polymorphism and multiple cancer risks
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