Abstract
Background: Metabolic syndrome (MetS) play a carcinogenic role in variety of cancers and influence the prognosis of cancer patients both systemically and hormonally.Methods: The data of clinicopathologic features and MetS of 808 gastric cancer patients and 1,146 randomly healthy controls were analyzed retrospectively.Results: Higher TG level, lower HDL-C level and higher hypertension frequency were observed in all gastric cancer patients when compared with healthy controls. While, gastric cancer patients had greater waist circumference only in females. Among three definitions of MetS, the MetS identified by the Chinese Diabetes Society (CDS) was associated with the most significant increasing risk of gastric cancer. Comparing all gastric cancer patients with healthy controls, OR of gastric cancer was enhanced by various individual components of the MetS, including higher TG level, lower HDL-C level, hypertension and diabetes; In male subgroup, OR of gastric cancer was enhanced by higher BMI, hypertension and diabetes; In females, OR of gastric cancer was enhanced by lower HDL-C, hypertension and diabetes. MetS was associated with poor differentiated carcinoma, more advanced pathological T, N stage and TNM stage of gastric cancer.Conclusion: The presence of MetS and its components were increased in gastric cancer, especially in gastric cancer patients with poor differentiation and advanced stage, which implies that metabolic disorder may play an important role in the development of gastric cancer.
Highlights
In the worldwide, gastric cancer is the fifth frequently diagnosed cancer with 952,000 new cases and 720,000 deaths in 2012 [1], which is more common in men and in developing countries [2]
The clinical and histopathological findings were assessed according to the 8th edition of gastric cancer tumornode-metastasis (TNM) staging system of the Union of International control Cancer (UICC) [26]
The differences between-group for each factor entered in the analysis
Summary
Gastric cancer is the fifth frequently diagnosed cancer with 952,000 new cases and 720,000 deaths in 2012 [1], which is more common in men and in developing countries [2]. In East Asia (involving Japan, China, and Korea), gastric cancer is a noticeable public health issue due to its highest morbidity and mortality. Metabolic Syndrome (MetS), which is defined by the presence of at least three out of the five factors: abdominal obesity, elevated triglycerides (TG), decreasing high-density lipoprotein cholesterol (HDL-C), hypertension and high fasting glucose, is becoming an universal and serious health problem all over the world [4]. Several expert groups have developed clinical criteria for the metabolic syndrome, while the most widely accepted clinical criteria were produced by the National Cholesterol Education Program-Third Adult Treatment Panel (NCEP-ATP III) and International Diabetes Federation (IDF) [5]. Metabolic syndrome (MetS) play a carcinogenic role in variety of cancers and influence the prognosis of cancer patients both systemically and hormonally
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