Abstract
Objective: To describe the prevalence of metabolic syndrome (MetS) in adolescents and its association with several MetS-related biochemical markers. Methods: A cross-sectional analysis was carried out and data were extracted from the Nutrition and Health Surveillance in Primary and Secondary school students of Beijing (NHSPSB) 2017. Participants were aged 10–15 years old. MetS was diagnosed using the recommended criteria for Chinese adolescents. The associations among MetS, biochemical biomarkers, and socioeconomic status were estimated by multivariable linear regression. Results: The prevalence of MetS in adolescents in Beijing was 3% in the total sample, 4% in boys, and 2% in girls. Moreover, the prevalence of MetS in the overweight and obesity populations were 5% and 12% respectively. The prevalence of MetS remained higher in boys than in girls. The concentrations of alanine aminotransferase (ALT), serum uric acid (SUA), low density lipoprotein (LDL), and C-reactive protein (CRP) were higher in the MetS children in comparison with non-MetS children (All p < 0.05), while the high-density lipoprotein (HDL) concentration was lower in MetS children. After adjusting for socioeconomic parameters in the multivariable regression model, MetS was strongly associated with ALT, SUA, HDL, and LDL. The five components of MetS indicated that abdominal obesity and a high serum triglyceride (TG) concentration were tightly linked with ALT, SUA, LDL, and CRP; while a low HDL concentration and elevated blood pressure were related to enhanced ALT, UA, and CRP. Additionally, impaired fasting glucose was only related to increased ALT. Conclusion: The epidemiological issues of MetS in Beijing adolescents should be known across socioeconomic classes. Early intervention strategies, such as dietary pattern interventions and physical excise, should be designed for that population to reduce the disease burdens of cardiovascular disease (CVD), Type 2 diabetes (T2D), and steatohepatitis in adulthood.
Highlights
Metabolic syndrome (MetS) is a cluster of several interrelated abnormalities including abdominal obesity, elevated blood pressure, impaired fasting glucose levels, high values of triglycerides (TG), Int
Metabolic syndrome and its associations with ALT, serum uric acid (SUA), low density lipoprotein (LDL) and C-reactive protein (CRP) in Beijing children were depicted in the present study
metabolic syndrome (MetS) was significantly associated with the ALT, SUA, LDL, and CRP concentrations
Summary
Metabolic syndrome (MetS) is a cluster of several interrelated abnormalities including abdominal obesity, elevated blood pressure, impaired fasting glucose levels, high values of triglycerides (TG), Int. J. Res. Public Health 2019, 16, 4557; doi:10.3390/ijerph16224557 www.mdpi.com/journal/ijerph. Res. Public Health 2019, 16, 4557 and low values of high-density lipoprotein (HDL) [1].The prevalence of MetS has been increasing dramatically around the world in the past decades. The age-standardized prevalence of MetS was 9.8%
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