Abstract
Background: In spite being only a cluster of conventional risk factors, metabolic syndrom (MetSy) has been recognized as independent predictor of cardiovascular diseases. We aimed to establish the association between metabolic syndrom and aortic pulse wave velocity (aPWV) as a measure of arterial stiffness in Czech general population. Methods: 576 subjects (mean age 48.03y (SD 14.8)), 41.5% males), a Pilsen sub-sample of postMONICA survey were included into the cross-sectional study. APWV was estimated using Sphygmocor device, subjects with MetSy was identified using common NCEP-ATPIII definition. Results: Subjects with MetSy showed significantly higher aPWW (9.02 vs. 7.42 m/sec, p < 0.001), also if diabetic (8.75 vs. 7.18, p < 0.001) or diabetic and hypertensive patients (7.96 vs. 6.84, p < 0.001) were excluded from analysis (p value adjusted for age). The significance of association between MetSy and aPWV remained even if adjusted for age, gender, current smoking, mean arterial pressure, serum glucose and other conventional risk factor as potential confounders (β=0,088, p = 0.023). Conclusion: In our sample of general population we found that MetSy represent an additive risk factor of aPWW, independent of age, blood pressure, glucose status (as established predictors of high arterial stiffness) (supported by the grant of Minístry of Health CR).
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