The Association between Mean Arterial Pressure, Central Venous Pressure, Cerebral Perfusion Pressure, Lung Oxygenation, and Glasgow Coma Scale in Sepsis Patients in the Intensive Care Unit

Abstract

BACKGROUND: Sepsis is the most frequent condition encountered in the intensive care unit (ICU). One of the neurological features of sepsis is sepsis-associated encephalopathy (SAE). The exact pathophysiology of SAE remains unclear. Many factors have been linked to SAE, such as hypotension, hypoxemia, and other metabolic abnormalities. However, alteration of cerebral blood flow is thought to be the main culprit behind SAE. AIM: This study aims to evaluate and find correlations between mean arterial pressure (MAP), central venous pressure (CVP), cerebral perfusion pressure (CPP), PaO2/FiO2 (PF) ratio, Glasgow Coma Scale (GCS), and level of consciousness. METHODS: A cross-sectional study was conducted from March 2020 to October 2020 in the ICU of H. Adam Malik Central Hospital, Medan, Indonesia. Patients over 18 years old with sepsis were included in this study. We recorded the demographic data, MAP, CVP, CPP, PF ratio, and GCS in the 1st h of ICU admission. The data were then analyzed to find the correlation between these parameters. RESULTS: The total subjects in this study were 62 patients, with an equal ratio of male-to-female. A quarter of the patients were intubated, affecting the GCS assessment. The median of GCS was 12. Most patients (46.8%) were determined to be somnolence. The mean age of the subjects is 54.84 ± 13.25 years old. There was no correlation between MAP, CVP, CPP, PF ratio, GCS, and level of consciousness in this study. CONCLUSIONS: Our study found no correlation between MAP, CVP, CPP, PF ratio, GCS, and level of consciousness in sepsis patients.