Abstract
Background: Multiple sclerosis (MS) is a common chronic genetic disease of the central nervous system. The relapsing-remitting-MS (RRMS) is the most common form of this disease. Matrix metalloproteinase-7 (MMP-7) is an important member of the MMP family, which degrades many extracellular matrix components. The common polymorphism of MMP-7 A-181G is associated with some diseases. Objectives: The aim of the present study was to determine the influence of this polymorphism on the risk of RR-MS. Materials and Methods: Eighty RR-MS patients and 80 healthy individuals as controls from the Kermanshah province were studied for MMP-7 A-181G polymorphism by using the PCR-RFLP method. Data were analyzed using the SPSS statistical software package version 16.0. Results: In RR-MS patients the frequency of MMP-7 GG genotype was significantly (P = 0.028) higher compared to that of the controls. The presence of GG genotype increased the risk of RR-MS by 1.69 times [OR = 1.69 and 95% CI = 1.05- 2.72, P = 0.03]. The frequency of MMP-7 G allele in RR-MS patients was significantly higher (51.2%, P = 0.043) than that of the controls (40%). The presence of this allele increased the risk of RR-MS by 1.58 folds (P = 0.044). Conclusions: Our findings indicate that the presence of G allele of MMP-7 A-181G polymorphism might increase the risk of RR-MS in our population.
Highlights
Multiple sclerosis (MS) is a common chronic genetic disease of the central nervous system
Due to inflammatory damages that lead to myelin destruction and failure in nerve conduction, the disease is exacerbated and this is responsible for disease relapse
In relapsing-remitting multiple sclerosis (RR-MS) patients the frequency of Matrix metalloproteinase-7 (MMP-7) GG genotype was significantly (P = 0.028) higher than that in controls (Table 2)
Summary
Multiple sclerosis (MS) is a common chronic genetic disease of the central nervous system. The frequency of MMP-7 G allele in RR-MS patients was significantly higher (51.2%, P = 0.043) than that of the controls (40%) The presence of this allele increased the risk of RR-MS by 1.58 folds (P = 0.044). Studies demonstrate that the risk of this disease in individuals with a family history of MS is more than those without a family history, suggesting a genetic susceptibility to MS disease [2] This disease has four clinically different forms including relapsing-remitting multiple sclerosis (RR-MS), primary-progressive multiple sclerosis (PP-MS), secondaryprogressive multiple sclerosis (SP-MS), and progressive-relapsing multiple sclerosis (PR-MS) [3]. The risk of RR-MS is twice in women compared to men During this phase of the disease, there are periods of relapsing and remitting. The majority of patients with RR-MS will develop SP-MS that is the more intense form of the disease and is accompanied by worsening of the clinical symptoms and decrease in parenchymal volume of the brain [4]
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