The association between K + and H + distribution in skeletal muscle: Implication to linked transport

Abstract

Data from the literature and results from a mathematical model of steady state fluid-electrolyte balance are used to support the observation that a relationship exists between the concentration gradients of K + and H + in the fluids of skeletal muscle over a range of acid-base disturbances. This relationship is shown to be consistent with the premise that the steady state electrochemical potential gradients for these ions remain constant under these conditions. Using a pump-leak model of ion transport, and the constant electric field assumption, it is also demonstrated that the steady state rates of active transport of K + and H + are related. These results suggest that the relations between both the steady state concentration gradients and the active transport rates for these ions are not necessarily the result of fixed biochemical mechanisms, but may come about simply from coupling through macroscopic thermodynamic processes.