Abstract
BackgroundAlthough the association between metabolic syndrome and intraocular pressure is well known, the relationship between the intraocular pressure and different combination of the components of metabolic syndrome has not been actively researched yet. The study aimed to investigate the relationship between the intraocular pressure and metabolic syndrome components with their different combinations.MethodsThirty-one thousand two hundred seventy one healthy people aged 19–79 who attended a community hospital for a health check-up between January 2011 and December 2013 were enrolled in the study. Subjects with a history of intraocular disease, at least in one eye and those receiving medical treatment for glaucoma were excluded. Metabolic syndrome was diagnosed following the criteria defined in Circulation 2009.ResultsSubjects with combination of three metabolic syndrome components of triglycerides, abdominal obesity, and fasting glucose had the highest intraocular pressure. And subjects with the combination of four components of blood pressure, high-density lipoproteins, triglycerides, fasting glucose had a significantly higher intraocular pressure than ones with the combination of all five metabolic syndrome components.ConclusionsThe difference in the risk of high intraocular pressure according to the different combination of the metabolic syndrome components could be confirmed. If additional follow-up studies are conducted, the findings can be used as an indicator for predicting intraocular pressure increases in patients with metabolic syndrome.
Highlights
The association between metabolic syndrome and intraocular pressure is well known, the relationship between the intraocular pressure and different combination of the components of metabolic syndrome has not been actively researched yet
Metabolic syndrome is a type of disease cluster in which the primary risk factors for cardiovascular diseases, such as hyperglycemia, hypertension, dyslipidemia, and abdominal obesity, occur simultaneously, and many studies have examined this since the World Health Organization (WHO) presented the criteria for defining metabolic syndrome (MetS) in 1998 [10]
High Blood pressure (BP) increases the pressure in the intraocular ciliary artery, which promotes the formation of the aqueous humor that increases the intraocular pressure (IOP), and, the association between IOP and hypertension has been confirmed in various studies [16, 17]
Summary
The association between metabolic syndrome and intraocular pressure is well known, the relationship between the intraocular pressure and different combination of the components of metabolic syndrome has not been actively researched yet. The study aimed to investigate the relationship between the intraocular pressure and metabolic syndrome components with their different combinations. A family history of glaucoma, high myopia, and high intraocular pressure (IOP) are known as risk factors of glaucoma [2]. Among the various known risk factors, IOP is considered the most important and controllable [3,4,5]. The diagnostic criteria for MetS were first announced in 1998 by the World Health Organization (WHO) [10]. Various organizations have proposed slightly different criteria in consideration
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