The Association between IL2 Genotypes and Risk and Severity of Chronic Periodontitis in a Chinese Han Population: A Case-control Study

Abstract

ABSTRACT Chronic periodontitis (CP) is a kind of multifactorial common oral diseases. Multiple immune molecules including interleukin-2 (IL-2) are involved in the occurrence and development of CP. To investigate the association between the IL2 rs2069762 polymorphism and the risk of CP in Chinese individuals, we recruited 375 CP patients and 443 controls in this case-control study. The PCR-RFLP method was used for genotyping. Data revealed that the GG genotype was related with a decreased risk of CP (GG vs TT: OR, 0.58, 95%CI, 0.37–0.92, P-value = 0.020; GG vs TG+TT: OR, 0.61, 95%CI, 0.39–0.94, P-value = 0.027). Besides, G allele was shown to decrease the risk of CP. In addition, the IL2 rs2069762 polymorphism was related with the severity of CP. To sum up, the IL2 rs2069762 polymorphism is related with a decreased risk and severity of CP in Chinese individuals.