THE ASSOCIATION BETWEEN HUMAN PAPILLOMA VIRUS AND LARYNGEAL MASSES

Ali Abdulsamad,Saad Abdulbaki,Isam Alshareda,Haider Al-Attar

doi:10.33762/bsurg.2019.164513

Abstract

The Human Papilloma Virus (HPV) can play a role in the development of head and neck tumors such as oropharyngeal tumors. Nevertheless, a real impact between Human Papilloma Virus and other head and neck sites such as the larynx is not well studied. This study aimed to assess the association of Human Papilloma Virus and laryngeal tumors. It is a prospective, case control study in which a random sample of 34 patients who have laryngeal masses was included in the period between November 2017 to December 2018. The study was carried out In the Department of Otolaryngology, Basrah Teaching Hospital. Patients were evaluated by a questioner according to gender, age, marital status, full medical history, and examination. A biopsy then was taken for histopathology study to confirm presence of tumors or other lesions. Malignant tumors were evaluated according to staging and grading systems. All lesions were examined for the presence of HPV by Immunohistochemistry (IHC) study. The results of this study revealed that there was HPV infection in 30% of the patients. Moreover, HPV was found in 30% of laryngeal squamous cell carcinoma and in 30% of benign lesions. Statistical tests showed no significant association between HPV and Laryngeal squamous cell carcinoma. In conclusion, although there was thirty percent of patients having HPV infections, but there was no significant association between HPV and laryngeal malignant tumours. A larger epidemiologic and more multicentric study is mandatory to evaluate the true prevalence of HPV infection in the mucosa of larynx and laryngeal malignancies. Keywords: Human, papilloma Virus, laryngeal tumors , immunohistochemistry, laryngeal mass

Highlights

The Human Papilloma Virus (HPV) can play a role in the development of head and neck tumors such as oropharyngeal tumors
Human papilloma virus immunohistochemistry was studied and showed that ten patients (29.4%) were positive, five patients were diagnosed as having benign lesions and the other five patients were diagnosed as malignant lesions
Laryngeal Papillomatosis is the most prevalent benign tumour of the larynx in children, and mother-tochild transmission is probably involved in juvenile-onset papillomatosis[18]

Summary

Introduction

The Human Papilloma Virus (HPV) can play a role in the development of head and neck tumors such as oropharyngeal tumors. This study aimed to assess the association of Human Papilloma Virus and laryngeal tumors. A larger epidemiologic and more multicentric study is mandatory to evaluate the true prevalence of HPV infection in the mucosa of larynx and laryngeal malignancies. While the different HPV proteins contribute to viral replication, the E6 and E7 viral oncoproteins are crucial in malignant transformation Together they can lead to epithelial cell immortalization. Affected cells lose their ability to repair DNA damage accumulate mutations and chromosomal instability This can eventually lead to cancer formation. The proliferation of the reserve cell (basal layer) which induced by HPV develops an alteration with a multilayered squamous cell epithelium formation and eventually papilloma can develop[7].

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