Abstract
BackgroundA fraction of patients with penetrating artery infarction (PAI) experience progressive motor deficit deterioration (PMD). We sought to investigate the role of high-sensitivity C-reactive protein (hs-CRP) at admission in predicting PMD.MethodsFrom January 2015 to September 2018, consecutive patients with PAI from three centers were prospectively enrolled in this study. PMD was defined as worsening of motor function score by ≥1 point on the National Institutes of Health Stroke Scale during the first 5 days after admission. Multivariable logistic regression analyses were performed to explore the relationship between hs-CRP and PMD in patients with PAI. We also performed receiver operating characteristic curve analysis and constructed a nomogram to assess the overall discriminative ability of hs-CRP in predicting PMD.ResultsWe ultimately included 544 patients (mean age, 65.4 ± 11.8 years). A total of 85 (15.6%) patients were identified to have PMD. Multivariate logistic regression analysis showed that hs-CRP was independently associated with PMD (P = 0.001). The optimal cutoff value for hs-CRP as a predictor for PMD was 3.48 mg/L, with a sensitivity of 73.64% and a specificity of 82.35% (area under curve, 0.792). Moreover, the nomogram we constructed indicated that higher level of hs-CRP was an indicator of PMD (c-index = 0.780, P < 0.001).ConclusionsOur study suggested that hs-CRP might be a useful biomarker for predicting the risk of PMD in patients with PAI.
Highlights
Ischemic stroke is one of the leading causes of mortality and disability worldwide [1,2,3]
Several inflammatory biomarkers was reported to be correlated with neurological deterioration in patients with acute ischemic stroke, such as lipoproteinassociated phospholipase A2, [16]. neutrophil– lymphocyte ratio [17] and so on
Previous studies have revealed that high-sensitivity C-reactive protein may act as an inflammatory factor that responds to ischemic stroke [18, 19]
Summary
Ischemic stroke is one of the leading causes of mortality and disability worldwide [1,2,3]. Progressive motor deficit (PMD) is one of the most common neurological deterioration during the acute stage of penetrating artery. Several inflammatory biomarkers was reported to be correlated with neurological deterioration in patients with acute ischemic stroke, such as lipoproteinassociated phospholipase A2, [16]. Previous studies have revealed that high-sensitivity C-reactive protein (hs-CRP) may act as an inflammatory factor that responds to ischemic stroke [18, 19]. The purpose of this tricenter observational study was to assess the association between hs-CRP levels at admission and PMD in patients with PAI. A fraction of patients with penetrating artery infarction (PAI) experience progressive motor deficit deterioration (PMD). We sought to investigate the role of high-sensitivity C-reactive protein (hs-CRP) at admission in predicting PMD
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
