The association between glycemic control and non-high density lipoprotein cholesterol in type 2 diabetic patients

Abstract

Introduction: Diabetes mellitus (DM) is a group of common metabolic disorders that is characterized by hyperglycemia. It is reported that most patients with Type 2 diabetes could have dyslipidemia at varying degrees, characterized by the increased levels of triglycerides (TGs) and low-density lipoprotein-cholesterol (LDL-C) and decreased high-density lipoprotein-cholesterol (HDL-C). The non-HDL-C was introduced to refine the risk estimation beyond LDL-C in the presence of elevated TGs levels ≥200 mg/dl, and it also estimates the level of all Apo-B-carrying lipoproteins. This study was conducted to correlate the glycated hemoglobin with non-HDL-C and lipid profile in Type 2 DM and non-DM patients. Materials and Methods: The present case and control study was conducted on 204 participants who attended the Medical Outpatient Department at KLE's Hospital, Belagavi, Karnataka, India. 102 Type 2 diabetic patients and 102 age- and gender-matched healthy controls were evaluated for serum fasting blood sugar (FBS), blood HbA1c, serum fasting lipid profile, and non-HDL-C. Data were analyzed using the SPSS software version. 20. Results: The results of our study showed that the mean ± standard deviation levels of FBS were 157.18 ± 41.8 and HbA1c was 8.19 ± 1.68, which were significantly increased in Type 2 diabetes patients as compared to controls with FBS 99.96 ± 12.94 and HbA1C 5.56 ± 0.40 with P