Abstract
MicroRNAs (miRNAs) participate in diverse biological pathways and may act as either tumor suppressor genes or oncogenes. Single nucleotide polymorphisms (SNPs) in miRNA may contribute to cancer development with changes in the microRNA's properties and/or maturation. Polymorphisms in miRNAs have been suggested in predisposition to cancer risk; however, accumulated studies have shown inconsistent conslusionss. To further validate determine whether there is any potential association between the four common SNPs (miR-196a2C>T, rs11614913; miR-146aG>C, rs2910164; miR-499A>G, rs3746444; miR-149C>T, rs2292832) and the risk for developing risk, a meta-analysis was performed according to the 40 published case-control studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the extent of the association. The results demonstrated that the rs11614913TT genotype was significantly associated with a decreased cancer risk, in particular with a decreased risk for colorectal cancer and lung cancer, or for Asian population subgroup. In addition, the rs2910164C allele was associated with decreased risk for esophageal cancer, cervical cancer, prostate cancer, and hepatocellular carcinoma (HCC), in particular in Asian population subgroup. Similarly, the rs3746444G allele was observed as a risk factor for cancers in the Asian population. It is concluded that two SNPs prsent in miRNAs(rs11614913TT, and rs2910164C) may protect against the pathogenesis of some cancers, and that the rs3746444 may increase risk for cancer.
Highlights
MicroRNAs are small, single-stranded, 19–21 nucleotide long non-protein-coding RNA molecules, functioning as negative regulators that involve post-transcriptional gene expression through binding to their target mRNAs regions and lead to mRNA cleavage or translational repression [1]
To determine the Single nucleotide polymorphisms (SNPs), genotyping by polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP) and TaqMan assay were performed in the 28 studies
When grouped by the cancer types, significant associations were still found in colorectal cancer (TT vs. CC: Odds ratios (ORs) = 0.70, 95% confidence intervals (CIs): 0.57–0.85, Ph = 0.284; TT+TC vs. CC: OR = 0.77, 95% CI: 0.65– 0.91, Ph = 0.377; TT vs. CC+TC: OR = 0.80, 95% CI: 0.69–0.94, Ph = 0.198), lung cancer(TT vs. CC: OR = 0.77, 95% CI: 0.65– 0.91, Ph = 0.284; TT+TC vs. CC: OR = 0.85, 95% CI: 0.74–0.98, Ph = 0.289; TT vs. CC+TC: OR = 0.83, 95% CI: 0.73–0.95, Ph = 0.281)
Summary
MicroRNAs (miRNAs) are small, single-stranded, 19–21 nucleotide long non-protein-coding RNA molecules, functioning as negative regulators that involve post-transcriptional gene expression through binding to their target mRNAs regions and lead to mRNA cleavage or translational repression [1]. Several studies have demonstrated that some polymorphism(SNPs) present in the miRNA genes, which can alter miRNA expression and/or maturation and be associated with the development and progression of cancer [6]. Four SNPs – miR-196a2C.T (or rs11614913), miR-146aG.C (rs2910164), miR-499A.G (rs3746444), and miR-149C.T (rs2292832) – identified in the pre-miRNA regions of miR-146a, miR-149, miR-196a2, and miR-499, respectively, have been reported to be associated with cancer risk [7,8]. To further determine whether there is an association of the four SNPs in the miRNA genes with the risk for developing cancer, a comprehensive review and analysis of published data from different studies is needed. We have extensively reviewed literature and performed a metaanalysis based on all eligible case-control published data to evaluate the association between the four polymorphisms and cancer susceptibility
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
