Abstract
Dyslipidemia, a major contributor to cardiovascular diseases, is rapidly increasing in Asian countries including Bangladesh. In addition to the cardiovascular system, abnormal lipid levels are also known to cause complications in renal and hepatic systems. The data regarding dyslipidemia and its relationship with liver enzymes are scarce for the Bangladeshi population. Therefore, this study was conducted to estimate the prevalence of dyslipidemia and determine the relationship between lipid profile and liver enzymes in Bangladeshi adults. A total of 405 participants (318 males and 87 females) were enrolled in the study. Serum levels of TG, TC, LDL, HDL and liver enzymes including ALT, AST, GGT and ALP were analyzed using standard methods. Dyslipidemia and liver function tests abnormalities were defined according to the international standard guidelines. The association between elevated lipid profile markers and liver enzyme abnormalities was assessed by logistic regression analysis. Overall, the prevalence of elevated TG, TC, LDL and low HDL were 30.9%, 23.7%, 26.2% and 78.8%, respectively. On the other hand, the prevalence of elevated liver enzymes ALT, AST, GGT and ALP were 18.8%, 21.6%, 12.9% and 21.9%, respectively. Dyslipidemia and liver enzyme abnormalities were higher in diabetic and hypertensive participants than in the healthy participants. About 61% of participants with dyslipidemia had at least one or more elevated liver enzymes. In regression analysis, an independent association was observed between serum GGT and all lipid components. In conclusion, a high prevalence of dyslipidemia and liver enzyme abnormalities were observed among the study participants. Of the four liver enzymes, the serum levels of GGT showed an independent association with all lipid components. Moreover, this study indicates that subjects with dyslipidemia often have a higher chance of having liver diseases than subjects with no dyslipidemia. However, large-scale prospective studies are needed to understand the underlying mechanisms of lipid-induced hepatic dysfunction in the Bangladeshi population.
Highlights
Rahanuma Raihanu Kathak, Abu Hasan Sumon, Noyan Hossain Molla, Mahmudul Hasan, Rakib Miah, Humaira Rashid Tuba, Ahsan Habib & Nurshad Ali *
The most common chronic liver disease represented by excess accumulation of lipids in the liver is known as non-alcoholic fatty liver disease (NAFLD)
There was a significant difference in the mean level of serum total cholesterol (TC), TG, low-density lipoprotein (LDL)-C, high-density lipoprotein (HDL)-C, fasting blood glucose (FBG) and alkaline phosphatase (ALP) (p < 0.05 for all cases) in the male and female groups
Summary
Rahanuma Raihanu Kathak, Abu Hasan Sumon, Noyan Hossain Molla, Mahmudul Hasan, Rakib Miah, Humaira Rashid Tuba, Ahsan Habib & Nurshad Ali *. In addition to the cardiovascular system, abnormal lipid levels are known to cause complications in renal and hepatic systems. The association between elevated lipid profile markers and liver enzyme abnormalities was assessed by logistic regression analysis. The prevalence of elevated liver enzymes ALT, AST, GGT and ALP were 18.8%, 21.6%, 12.9% and 21.9%, respectively. A high prevalence of dyslipidemia and liver enzyme abnormalities were observed among the study participants. The most common chronic liver disease represented by excess accumulation of lipids in the liver is known as non-alcoholic fatty liver disease (NAFLD) It is the most common form of hepatic disorder in the developed nations and is predicted to be identical for developing nations in the d ecades[13,14]. Serum ALT is considered as a specific marker for hepatic damage and is mainly found in this organ[17,18,19], while serum
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
