Abstract
Background Myocardial fibrosis and abnormalities of the microcirculation are features of non-ischemic dilated cardiomyopathy (DCM) and may contribute to adverse remodeling. However, relationship between perfusion abnormalities and diffuse fibrosis has not been fully characterised. CMR allows quantification of the extracellular volume fraction (ECV), a marker of fibrosis, and absolute myocardial blood flow, in a single study. We hypothesised that increased ECV was associated with impaired myocardial perfusion reserve (MPR) in DCM patients. Methods
Highlights
Myocardial fibrosis and abnormalities of the microcirculation are features of non-ischemic dilated cardiomyopathy (DCM) and may contribute to adverse remodeling
We hypothesised that increased extracellular volume fraction (ECV) was associated with impaired myocardial perfusion reserve (MPR) in DCM patients
1CMR Unit, Royal Brompton Hospital, London, UK Full list of author information is available at the end of the article stress and rest global myocardial blood flow quantified by a Fermi-constrained deconvolution algorithm
Summary
Aamir Ali1*, Li-Yueh Hsu, Ankur Gulati, Tevfik Ismail, Claire E Raphael, Vassilis Vassiliou, Navtej Chahal, Kaushiga Krishnathansan, Natasha Davendralingam, Carla Goncalves, Ricardo Wage, Pedro Ferreira, Arun J Baksi, Peter Gatehouse, David Firmin, Dudley J Pennell, Peter Kellman, Andrew E Arai, Sanjay K Prasad. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. 16-19 January 2014
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