Abstract
BackgroundIsoflavones, a class of phytoestrogenic compounds, are abundant in soybeans. A number of epidemiological studies have investigated the association between dietary isoflavones intake and the risk of gastric cancer. However, the results are inconclusive. Therefore, the meta-analysis was conducted to evaluate the effect of dietary isoflavones intake on the risk of gastric cancer.MethodsRelevant studies from May 1992 to May 2017 were identified through searching PubMed and Web of Science. Additional articles were identified from the reference lists of relevant review articles. Pooled risk ratios (RRs) or odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a fixed-effects model. Funnel plot and Egger’s test were used to evaluate publication bias.ResultsSeven articles reporting 12 studies were included in the current meta-analysis. We found no significant association between dietary isoflavones intake and gastric cancer risk with the highest versus the lowest categories of dietary isoflavones intake (OR = 0.97, 95% CI = 0.87–1.09, I2 = 27.5%). Subgroup analyses generally yield similar results.ConclusionsHigher dietary isoflavones intake is not associated with a decline in the risk of gastric cancer.
Highlights
Isoflavones, a class of phytoestrogenic compounds, are abundant in soybeans
Epidemiological studies have suggested that high fruits and vegetables intake are inversely associated with the risk of gastric cancer [2, 3]
Inclusion criteria and exclusion criterion Studies were selected for analysis according to the following inclusion criteria: (1) investigated the relationship of dietary isoflavones intake and gastric cancer risk; (2) the studies were either cohort or case-control studies; (3) articles reported the estimated risk ratios (RRs)/odds ratios (ORs) with their 95% confidence intervals (CIs) or the indexes could be calculated. (4) articles were published in English literature
Summary
Isoflavones, a class of phytoestrogenic compounds, are abundant in soybeans. A number of epidemiological studies have investigated the association between dietary isoflavones intake and the risk of gastric cancer. The meta-analysis was conducted to evaluate the effect of dietary isoflavones intake on the risk of gastric cancer. Gastric cancer, including gastric adeno-carcinoma and gastric cardia adeno-carcinoma, was the third leading cause of death in the world which accounting for 8. 8% of the total cancer death, according to GLOBOCAN 2012 [1]. It is estimated that there were 951,600 new gastric cancer cases and 723,100 deaths occurred in 2012. Epidemiological studies have suggested that high fruits and vegetables intake are inversely associated with the risk of gastric cancer [2, 3].
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