Abstract
Purpose. To investigate the oxidant and antioxidant status of patients with type 2 diabetes mellitus and nonproliferative diabetic retinopathy (DRP). Methods. Forty-four patients who had cataract surgery were enrolled in the study. We included 22 patients with DRP in one group and 22 patients in the control group. Samples of aqueous humor and serum were taken from all patients. Serum and aqueous ischemia-modified albumin (IMA), total thiol, total antioxidant capacity (TAC), and total oxidative stress (TOS) levels were compared in two groups. Results. Median serum IMA levels were 44.80 absorbance units in the DRP group and 40.15 absorbance units in the control group (P = 0.031). Median serum total thiol levels in the DRP group were significantly less than those in the control group (3051.13 and 3910.12, resp., P = 0.004). Mean TOS levels in the serum were 2.93 ± 0.19 in the DRP group and 2.61 ± 0.26 in the control group (P = 0.039). The differences in mean total thiol, TAC, and TOS levels in the aqueous humor and mean TAC levels in the serum were not statistically significant. Conclusion. IMA, total thiol, and TOS levels in the serum might be useful markers in monitoring the risk of DRP development.
Highlights
Diabetes mellitus (DM) is a common disease around the world
Patients were classified into two groups: 22 patients with type 2 DM and nonproliferative Diabetic retinopathy (DRP) were included in DRP group and 22 patients were included in the control group
Median serum Ischemia-modified albumin (IMA) levels were 44.80 absorbance units in the DRP group compared with 40.15 absorbance units in the control group (P = 0.031)
Summary
Diabetes mellitus (DM) is a common disease around the world. Diabetic retinopathy (DRP) is one of the main reasons of blindness [1, 2]. There was no study found in the literature assessing the total thiol levels in the serum and aqueous humor of patients with DRP. The main risk factors (glycosylated hemoglobin concentration, duration of Journal of Ophthalmology diabetes, and blood pressure) are thought to correlate with the incidence and progression of DRP, they can explain only a limited amount of the risk of developing these complications [19, 20]. These factors are not efficacious in observing the amount of tissue ischemia caused by DM. We examine the oxidant and antioxidant status of patients with type 2 DM who had nonproliferative DRP and compare them with those of age and sex matched patients in the control group
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
