Abstract
BackgroundBrain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis. This study attempted to elucidate the role of the BDNF variant rs6265 in emotional symptoms following mild traumatic brain injury (mTBI).MethodsTo investigate the association between BDNF Val66Met polymorphism (rs6265) and emotional symptoms in mTBI patients, we recruited 192 mTBI patients and evaluated their Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores in the first and sixth week after mTBI.ResultsThe patients carrying the T allele of rs6265 had significantly higher BAI scores in the first week following mTBI. In addition, the patients carrying the T allele also showed higher scores of BDI in the first week. In the gender-specific subgroup analysis, the male patients carrying the T allele of rs6265 had higher scores of both BAI and BDI in the first and sixth week. Meanwhile, female patients carrying the T allele also had significantly higher scores of BDI in the first week following mTBI.ConclusionsThis study provides evidence for the association between the BDNF variant rs6265 and emotional symptoms following mTBI.
Highlights
Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis
Subject recruitment Patients aged ≥ 20 years who had been diagnosed with mild traumatic brain injury (mTBI) in the emergency department were recruited from three Taipei Medical University (TMU) affiliated hospitals, including TMU Hospital, Wan Fang Medical Center, and Shuang Ho Hospital
Females accounted for 68.2% (131/192) of total recruited patients
Summary
Brain-derived neurotrophic factor (BDNF) is one of the most abundant neurotrophins in the adult brain, and it plays important roles in modulating synaptic plasticity and synaptogenesis. This study attempted to elucidate the role of the BDNF variant rs6265 in emotional symptoms following mild traumatic brain injury (mTBI). Methods: To investigate the association between BDNF Val66Met polymorphism (rs6265) and emotional symptoms in mTBI patients, we recruited 192 mTBI patients and evaluated their Beck Anxiety Inventory (BAI) and Beck Depression Inventory (BDI) scores in the first and sixth week after mTBI. Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. The rates of TBI-related emergency department (ED) visits have been estimated to be increased by 70% over the past decade. In 2010, The Center for Disease Control and Prevention (CDC) reported that 2.5 million ED visits, hospitalizations, and deaths are associated with TBI in the United States. Current data indicate that about 3.2 ~ 5.3 million persons in the United States are living with disabilities related to TBI [1, 2].
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