Abstract
Arrhythmia is a common disease around the world and Helicobacter pylori (H. pylori) is a bacterium infecting 28% to 84% of subjects, depending on the population tested. However, the implication of H. pylori in cardiac arrhythmia is poorly understood. We performed this meta-analysis with an aim to identify the association between arrhythmia and H. pylori. We searched PubMed, Embase, Web of Science, and the Cochrane library databases to select studies on the association between arrhythmia and H. pylori. In the arrhythmia group, 392 (58.1%) were H. pylori-positive and in the control group 640 (47.8%) were H. pylori-positive. Compared to the controls, the infection rate of H. pylori was higher in patients with arrhythmia than in controls (odds ratio (OR) = 1.797, 95% confidence interval (CI): 1.081–2.988, p < 0.05). Subgroup analysis indicated that H. pylori infection was a risk factor for atrial fibrillation in Asia and Africa. Therefore, a correlation between H. pylori infection and arrhythmia may exist and H. pylori eradication may decrease the occurrence of arrhythmia, especially in Asia and Africa.
Highlights
Arrhythmias are common and are increasing, atrial fibrillation
We provided an overview of the relationship between H. pylori infection and arrhythmia with a total of 2014 subjects
Six studies investigated the association between H. pylori infection with arrhythmia
Summary
Arrhythmias are common and are increasing, atrial fibrillation. Arrhythmias may be divided into different categories based on various criteria. Based on the beating rate, arrhythmias include bradyarrhythmia and tachyarrhythmia. Arrhythmias can be divided into supraventricular and ventricular arrhythmias depending on the pathogenic area [1]. The lifetime risk for the development of atrial fibrillation is about one in four for men and women over 40 years old [2]. The symptoms associated with arrhythmias include chest distress, chest pain, and headache
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