The Association Between 25-hyroxyvitmin D Concentration and Macronutrients Consumption with Obesity-related Variables in Korean Women (P18-062-19)

Abstract

ObjectivesDeficiency of vitamin D is increasing in worldwide and has been reported to be associated with chronic disease such as obesity, cardiovascular disease, and hypertension. The risk of vitamin D deficiency and chronic disease is related with higher prevalence after menopause. MethodsUsing a cross-sectional study of 8726 Korean women, this study was investigated combined interaction effect of vitamin D concentration and dietary macronutrients consumption on obesity-related variables in relation to menopausal status. ResultsThe percentage of vitamin D insufficient (vitamin D < 50 nmol/L) in premenopausal and postmenopausal women was 84.5% and 67.7%, respectively. The subjects with vitamin D insufficient group had higher obesity-related variables such as BMI (P = 0.019), FG (P = 0.019), TG (P < 0.001), and HDL-C (P = 0.006) than those in the vitamin D sufficient group (vitamin D ≥ 50 nmol/L). The interaction effect of menopausal status and vitamin D concentration on obesity-related variables significantly differ. The subjects with vitamin D insufficient group among postmenopausal women had higher BMI (P < 0.001), waist circumference (P = 0.011), fasting glucose (P = 0.035) and triglycerides (P = 0.001) compared to those with sufficient group. Also, among only postmenopausal women, the subjects who were vitamin D insufficient, the risk of obesity was significantly increased by 1.1297 (95% CI = 1.078–1.560) using the vitamin D sufficient as reference. However, the obesity-related variables and risk of obesity according to vitamin D concentration did not differ among premenopausal women. Moreover, among the subjects with a low dietary protein consumption, the subjects in vitamin D deficient had an increasing trend in the risk of obesity by 1.308 times (95% CI = 1.039–1.647) than those with sufficient group. However, those findings did not differ among premenopausal women. ConclusionsThus, the risk of obesity due to vitamin D deficient in postmenopausal women may be modified by the consumption of dietary protein. Funding SourcesThis study was supported by the research funds of Kunsan National University and the Basic Science Research Program of the National Research Foundation of Korea (NRF) funded.