The association among prematurity, cochlear hyperintensity, and hearing loss.

Abstract

Background Prematurity is a major risk factor for neonatal hearing loss. Recent advancements in magnetic resonance imaging (MRI) have made it possible to evaluate structural details of the membranous labyrinths in premature infants that have heretofore been inaccessible. Objective We compared the prevalence of abnormal cochlear signal intensity in premature and term neonates and evaluated for a potential link with hearing loss. Materials and methods We retrospectively reviewed 148 consecutive MR exams performed in premature (< 37 weeks' gestation) and term neonates performed over a 30-month period. Cochlear signal alteration was evaluated on three-dimensional T1-weighted imaging (T1WI) sequences. Each patient's electronic medical record was reviewed to document demographics, symptomatology, physical exam findings, and potential medical variables that could contribute to cochlear signal alteration. Results Cochlear hyperintensity on T1WI was present in 6.8% patients ( n = 10) overall, but was much more common in preterm than term patients (12.2% (9 of 74) vs. 1.4% (1 of 74), respectively; p value < 0.05; Fisher's exact test). Overall, 14.9% ( n = 15) of the patients with hearing test results failed the screening Auditory Brainstem Response exam. However, failure was much more common among patients with cochlear hyperintensity on T1W1 than those with normal findings (56% (5 of 9) vs. 11% (10 of 92), respectively; p value < 0.01; Fisher's exact test). Conclusion Cochlear hyperintensity on T1WI is more common in preterm than term neonates, and potentially associated with hearing loss. Cochleae should be closely scrutinized in all premature infants; signal alterations should prompt further diagnostic inquiry and possible early otolaryngology referral.