The assessment value of peripheral blood eosinophils for treatment prognosis of chronic rhinosinusitis

Abstract

Objective:The purposes of present study were to explore the relative factors affecting treatment outcomes of chronic rhinosinusitis(CRS),and investigated the clinical manifestation changes of CRS patients after post-operative treatment of oral glucocorticoid. Method: Forty-eight CRS subjects including 14 illness un-controlled group, and 34 illness controlled group were enrolled, and peripheral blood leukocytes, eosinophils, neutrophils, mononuclear cells, lymphocytes were detected and clinical features comprised of VAS, endoscopy and CT scan scores were recorded; 20 days'oral glucocorticoid was prescribed to the patients in illness un-controlled group and the data described above were analyzed. Result:Compared to illness controlled group, illness uncontrolled subjects had higher peripheral blood eosinophils count(P=0.028), and complicated with higher rate of allergic rhinitis(P=0.035), asthma(P=0.024), atopy patients(P=0.042); the eosinophils was positively correlated with total VAS scores(R=0,410, P=0,007); the eosinophils count(P=0.007), total VAS scores(P<0.001), total endoscopy scores(P=0.001) were significant decreased after oral glucocorticoid treatment. Conclusion: Allergic rhinitis, asthma, atopy, and elevated eosinophils counts were risk factors of the prognosis of CRS, oral glucocorticoid treatment showed additional benefit to the illness un-controlled CRS subjects, and blood eosinophils count was an important predictive factor for clinical manifestation of CRS.