Abstract
Objective:Thyroid hormone abnormalities are commonly seen in polycystic ovary syndrome (PCOS) and have considerable effects on comorbidities. The association with PCOS and thyroid autoimmunity which lead to thyroid pathologies are not revealed clearly. We targeted to commentate anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG) antibody levels and thyroid autoimmunity in PCOS.Material and Methods:One hundred eighty four patients who got the diagnosis of PCOS regard to the revised 2003 Rotterdam criteria were embodied in this study. One hundred six age-matched female volunteers were included in the control group. Characteristics, biochemical parameters, thyroid hormone and autoantibody levels of groups were investigated.Results:Although; we did not find out a statistically significant difference in TSH and sT4 levels between two groups (p>0.05), anti-TPO and anti-TG antibody levels were determined higher in PCOS group significantly (p<0.001). Anti-TPO Ab and anti-TG Ab positivity prevalence of PCOS patients were significantly higher as against to controls (p<0.001; p=0.01).Conclusion:Not only thyroid hormone levels but also thyroid autoantibody levels should be screened during the investigation of PCOS and the patients with positive results need to be followed up carefully in the long run.
Highlights
Polycystic ovary syndrome (PCOS) is a prevalent endocrinologic disorder affect women at the fertility period [1]
Individuals who have the diagnosis as hyperprolactinemia, congenital adrenal hyperplasia, androgensecreting tumours, Cushing syndrome, hypertension, hepatic or renal insufficiency, diabetes mellitus and concurrent thyroid dysfunction were excluded from the study
Thyroid stimulating hormone (TSH) and free T4 levels were quantified via chemiluminescent microparticle immunoassay (Abbott, Architect i2000, Abbott Laboratories Diagnosis Division, IL, USA)
Summary
Polycystic ovary syndrome (PCOS) is a prevalent endocrinologic disorder affect women at the fertility period [1]. PCOS is identified with menstrual irregularity, hyperandrogenism, and infertility [2]. Metabolic syndrome, dyslipidemia, insuline resistance, type 2 diabetes mellitus, and cardiovascular disorders are the most common comorbidities related to this syndrome [3,4,5,6]. Autoimmune thyroid disease prevalence in women is 4% and rises up to 15% in the event of existing thyroid autoantibody positivity [7]. Thyroid hormone dysfunctions and thyroid autoimmunity cause abnormalities on sex hormone metabolism, menstrual irregularities and infertility [8,9]. Anti-thyroid peroxidase antibodies (anti-TPO Ab) and antithyroglobulin antibodies (anti-TG Ab) are fundamental markers of thyroid autoimmunity. A study by Poppe et al [8] demonstrated that thyroid auto antibodies are significantly
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