Abstract
The long-term persistence of Helicobacter pylori infection with the increased concentration of hydrochloric acid and pepsins increases the aggressive properties of the gastric juice. These changes may contribute to development of the ulcer disease. Further progression of the pathological process leads to occurrence of atrophy, intestinal metaplasia, dysplasia, and may end with gastric cancer. 280 children with chronic gastroduodenal pathology have been examined. The presence of Helicobacter pylori has been examined by both rapid urease test and urease breath test. The concentration of pepsinogens in the blood serum and acidity of the gastric juice have been studied in all patients under research. The significant changes in the secretory function of the gastric mucosa have been revealed in children with chronic gastroduodenal pathology. The persistence of Helicobacter pylori, increase of the pepsinogens and hydrochloric acid concentration in the gastric juice leads to development of erosive and ulcerative changes in the mucosa of the duodenum in children. In addition, the long-term course of chronic gastroduodenal pathology with persistence of Helicobacter pylori may cause development of atrophic processes in the mucosa in childhood. It can not be always possible to diagnose these changes by using biopsy of the gastric mucosa. Determination of the level of pepsinogens in the blood serum and diagnosis of Helicobacter pylori by non-invasive methods can be effectively used as detection of the severity of the inflammation process in the mucosa of the stomach and duodenum in children.
Highlights
The endoscopy with gastrobiopsy is the main diagnostic method for verification of the atrophic process in the gastric mucosa
All patients were divided into four groups of comparison: group I – 50 (17.9±2.3%) children with chronic gastroduodenitis (CGD), which is not associated with Helicobacter pylori (HP)-infection (HP-), group II – 50 (17.9± ±2.3%) with CGD associated with HP (HP+), group III – 60 (21.4± ±2.5%) with duodenal ulcer disease (UD), group IV – 120 (42.9±3.0%) with erosive bulbitis (EB)
The comparison of the indices of the PG level and the data of intragastric pH-metry has allowed to evaluate the condition of the secretory function in children with chronic gastroduodenal pathology (CGDP)
Summary
The endoscopy with gastrobiopsy is the main diagnostic method for verification of the atrophic process in the gastric mucosa. PGs are secreted in cells of the mucous membrane of the stomach and converted to pepsin by autocatalysis in the presence of hydrochloric acid. They can be subdivided on the basis of their physical properties into two major groups: pepsinogen I (PG1) and pepsinogen II (PG2). The measurement of PG1 and PG2 in the blood serum is considered to be one of the non-invasive biochemical markers for monitoring peptic secretion and obtaining information on the gastric mucosa status in patients. The reduced of concentration of PG1 and PG2 in the blood serum in the patients with the longterm CGDP may be associated with development of atrophic processes in the mucous membrane of the stomach
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
