Abstract
Objective: To evaluate five drug treatment regimens in the treatment of Brucella spondylitis. Methods: Patients with clinical symptoms compatible and diagnostic test consistent with Brucella spondylitis were randomly assigned to five drug treatment regimens. Results: Combination therapy with doxycycline, rifampin and sulfamethoxazole for 56 consecutive days showed the highest cure rate of 20% after a single course and of 85% after a double course with affectivity rates of 55% and 95%. Cure rate and affectivity rate was significant better (P 0.05) than for patients receiving doxycycline, rifampin and streptomycin for the same period and regimens containing doxycycline were significant better than regimens without this drug. Conclusion: Combination therapy of doxycycline, rifampin and sulfamethoxazole for 8 weeks using one or two full courses should be recommended for Brucella spondylitis.
Highlights
Estimating Brucellosis is a infectious allergic diseases caused by bacterium burgeri, which can happened in both human beings and animals, with very broad endemic regions
The strain, susceptible population and route of transmission have changed that the bovine type, caprine type and swine type bacterium burgeri can be spread to human beings by contacting damaged skin or membrana mucosa directly and by intaking contaminated food
Bones and joints often invaded by the disease, and the two consecutive segments of the spine are most commonly involved, which can triggered spondylitis and discitis leading to large devastating spine combined with spinal instability and spinal cord, cauda eguina or root compression [1,2,3,4,5,6,7,8] (Figure 1)
Summary
Estimating Brucellosis is a infectious allergic diseases caused by bacterium burgeri, which can happened in both human beings and animals, with very broad endemic regions. The strain, susceptible population and route of transmission have changed that the bovine type, caprine type and swine type bacterium burgeri can be spread to human beings by contacting damaged skin or membrana mucosa directly and by intaking contaminated food. Related clinical application finds that the classic drug treatment and compatibility have less clinical effective to the Brucella spondylitis disease and to relapse [9,10,11,12,13,14]. Ity of the program and getting the best method of treatment have a positive effect to cure early Brucella spondylitis, reduce disability, avoid the surgical risk and prevent the recurrence which are reported as follows:
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