Abstract
The pharmacokinetics of teicoplanin in patients with severe burns has been assessed using two different numerical methods: a nonlinear curve fitting procedure and quantified maximum entropy. On the whole nonlinear curve fitting and quantified maximum entropy provided different pharmacokinetic parameter estimates for the same sets of data. With respect to correctness and reliability of the values, quantified maximum entropy appears to be the better approach. However, its full success depends on the data available. The data material need to be comprehensive to assure a maximum information content to be extracted. The nonlinear curve fitting approach requires less sophisticated mathematical modelling which is possible on common hardware, and produces results faster than quantified maximum entropy. Thus, nonlinear curve fitting is the method of choice if a rapid assessment of the data is required, whereas quantified maximum entropy should be the method of choice in research and development, where the required accuracy of the estimates is more important than time.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
