The Assessment of Immunological Status in Hemodialysis Patients Post COVID-19 Infection

Abstract

Abstract Background Coronavirus disease 2019 (COVID-19) infection emerged in Wuhan, China in December 2019 and has spread rapidly worldwide. On March 11, 2020, WHO declared COVID-19 a pandemic. COVID-19 is a single-strain RNA virus that typically causes respiratory damage in humans and animals. Aim of the Work Detection of the level of immunoglobulin (IgG) antibodies against covid -19 virus to assess the immunological status of the patients post covid-19 infection and the risk of reinfection with covid -19 Patients and Methods This study is Cohort study, was carried out Hemodialysis unit in Nephrology department, Ain shams university Hospital and Ain shams specialized Hospital, on 60 of heamodialysis patients divided into these three groups; (Group 1): included 20 patients that have been infected with covid 19 and confirmed positive by PCR test, (Group 2): included 20 patients who were highly suspected infection with covid-19 by CT findings, (Group 3): included 20 patients with no history suggestive of covid-19 infection during the pandemic as acontrol study group. Results There is astrong significance between between patients in group A (who are confirmed positive covid 19 infection by pcr test) and group B (who are suspected covid infection by ct or symptoms and laboratory findings) and group C (who are not infected or have symptoms) as regard hospital admission and home isolation. There is a significance between patients in group A (who are confirmed positive covid 19 infection by pcr test) and group B (who are suspected covid infection by ct or symptoms and laboratory findings) and group C (who are not infected or have symptoms) as regard lymphocyte count during infection, and shows that there is no significance between the groups as regard (HB, MCV, MCH, MCHC, WBCS, Platelets). Significance positive Correlation of IgG Titer with age and there is a significance positive correlation of hospital admission duration with BMI in COVID suspected patients by CT (n = 20). There is a significance between duration of infection and IgG titre as patients who were 3 months from infection have strong significans more than who were 6 months or more from infection, and there is no significance between duration of infections and labs findings. There is significance between IgG titre and duration from infection in group A and group B if the duration of infection was less than 6 months or more than 6 months. Conclusion There was significance between patients in group A, group B and group C as regard IgG titer. There was significance negative Correlation of IgG Titer and hospital admission duration with lymphocytes count during infection and duration form infection respectively in COVID patients confirmed by PCR (n = 20). There was significance positive Correlation of IgG Titer with age and there was a significance positive correlation of hospital admission duration with BMI in COVID suspected patients by CT (n = 20).