THE ASSESSMENT OF BIOMARKER COMPLEX IN MEN WITH CORONARY ATHEROSCLEROSIS

Abstract

Aim. To study relation of antioxidant status, lipid and carbohydrate metabolism and to evaluate the influence of these factors on coronary atherosclerotic lesions vulnerability. Material and methods. Totally, 104 men included — mean age 60,74±8,1 y., selected to control (non-CHD) and main group with angiographically verified coronary atherosclerosis and CHD. Main group was divided to 2 subgroups. The first included 38 men, who had unstable plaques, the second — 34 men who had been diagnosed only stable plaques in coronary arteries. In all serum specimens we measured: malonic dialdehyde concentration (MD); oxidation resistance of low density lipoproteides (LDL), general level of oxidation stress; level of retinol, β-carotene in LDL; total cholesterol; high density cholesterol (HDL); cholesterol of low density lipoproteides (CLDL); triglycerides (TG); glucose; C-peptide and insulin. Statistics was done on the SPSS software (13.0). Results. In men with coronary atherosclerosis, comparing to the control group, among the studied complex of lipid-lipoproteide, carbohydrate and oxidation-antioxidant biomarkers in blood there were elevated CLDL, TG, ApoB, relation ApoB/ApoA, LP(a), C-peptide, grade of oxidation stress and CHDL level decreased, as retinol, β-carotene and LDL resistance to oxidation. Existence of unstable atherosclerotic lesions in vessel wall determined interrelation of CHDL with TG (p<0,01) and resistance of LDL to oxidation (p<0,05). Also, as in the second subgroup the level of CHDL correlated with CLDL (p<0,01), β-carotene and retinol (p<0,05). While studying the relation of lipid and carbohydrate metabolisms there was relation of glucose level with those parameters as CHDL, CLDL, TG (p<0,01), apo B, LP(a), ApoB/ApoA (p<0,05). Conclusion. The data obtained in the study points on the relation of parameters of lipid, carbohydrate and oxidation-antioxidant status with coronary atherosclerosis development and possibility of atherosclerotic lesion instability.