The assessing method for multimolecular forms of plasminogen in an individual human blood

Abstract

Several multimolecular forms have been reported in human native plasminogen. This paper deals with the assessing method for multiforms of plasminogen, and multiform patterns obtained in healthy adults, newborns and patients with renal disease.The multiforms in individuals were assessed by disc gel electrophoresis with continuous buffered system containing EACA. As the mobility of each subform to myoglobin was highly reproducible, the mobility of each form of plasminogen from various origin could be compared. Purified plasminogen from most of persons was consisted of five major native plasminogens and a few minor ones. Furthermore, the mobility of each subform was identical in three groups. The results obtained suggested that the neonatal and adult plasminogen might be synthesized by the same gene.