Abstract
IT is WELL known that Dale (1) and Cushny (2) independently discovered that the stimulation of the sympathetic fibers innervating the uterus of the cat produces relaxation of that organ in non-pregnant animals whereas a contraction is observed in pregnant animals. Van Dyke and Gustavson (3) were able to elicit a pregnancy-response (contraction) in ovariectomised non pregnant cats by injecting a crude corpus luteum extract which probably contained considerable amounts of estrin. Estrin alone was without such action. Progesterone has since become available and was used by Kennard (4) who, however, employed large doses and did not first sensitize the uterus by injecting an estrogen. In a preliminary report, van Dyke (5) pointed out that progesterone (and hence progesterone-containing extracts) can be assayed by means of the induction of a pregnancy-response in normal or ovariectomized cats. The work here reported represents a detailed and rather extensive study of the conditions under which assay can be acco...
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