Abstract
The asbestos paradox: global gaps in the translational science of disease prevention.
Highlights
Mesothelioma, a malignant cancer of the pleura, is almost exclusively associated with asbestos exposure.[1]
Regional disparities persist in translating scientific knowledge of asbestos risks to policy for preventing cancers and other diseases
Most cases of mesothelioma are found in countries producing asbestos and in developing countries using the products, where scientific knowledge of asbestos toxicity seems to have been lost in translation.[3]
Summary
Mesothelioma, a malignant cancer of the pleura, is almost exclusively associated with asbestos exposure.[1]. Regional disparities persist in translating scientific knowledge of asbestos risks to policy for preventing cancers and other diseases. Most cases of mesothelioma are found in countries producing asbestos and in developing countries using the products, where scientific knowledge of asbestos toxicity seems to have been lost in translation.[3] It is in these countries, where affected populations are less likely to have access to prompt diagnosis, health care or litigation, that we will observe the wave of mesothelioma cases.[3] A perspective on three scientific translational gaps is presented here: (i) making policy decisions within the context of scientific uncertainty, (ii) the role of alternative assessments in selecting safer commercial materials, and (iii) the translation of scientific evidence into disease prevention.
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