Abstract
Architectural proteins play an important role in organizing and compacting the genome in all three kingdoms of life. Archaeal chromatin proteins show similarities with both bacterial and eukaryotic chromatin proteins.The thermophilic model organism Sulfolobus expresses four different chromatin proteins: Cren7, Sul7, Alba and Sso10a. To characterize the architectural properties of these proteins we use a single-molecule approach. We have observed that these proteins are all able to compact DNA, exhibiting different sets of binding modes. In addition to DNA compaction and organization, these proteins are believed to play an important role in maintaining genome integrity at high environmental temperatures. High temperature single-molecule measurements showed how DNA structure is affected by temperature and how chromatin proteins affect DNA stability at these temperatures.View Large Image | View Hi-Res Image | Download PowerPoint Slide
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
