Abstract
The Archaeal Exosome: Identification and Quantification of Site-Specific Motions That Correlate with Cap and RNA Binding
Highlights
Large molecular machines perform many cellular processes and it is of fundamental interest to understand how these enzyme complexes work in detail
The archaeal and eukaryotic exosome complexes consist of nine subunits arranged in a hexameric ring structure that interacts with a trimeric cap structure.[8]
A number of crystal structures of the archaeal exosome have been solved that show that the RNA is funneled through a hole at the top
Summary
Large molecular machines perform many cellular processes and it is of fundamental interest to understand how these enzyme complexes work in detail. The assignment of the methyl groups in the exosome core complex revealed that a subset of the residues gives rise to two sets of resonances (Figure 1 A), which indicates that the complex adopts two structurally different conformations in solution.
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