Abstract
In recent years, the morbidity and mortality of gastrointestinal cancer have remained high in China. Due to the deep location of the gastrointestinal organs, such as gastric cancer, the early symptoms of cancer are not obvious. It is generally discovered at an advanced stage with distant metastasis and lymph node infiltration, making it difficult to cure. Therefore, there is a significant need for novel technologies that can effectively diagnose and treat gastrointestinal cancer, ultimately reducing its mortality. Gold nanoparticles (GNPs), a type of nanocarrier with unique optical properties and remarkable biocompatibility, have the potential to influence the fate of cancer by delivering drugs, nucleic acids to cancer cells and tissues. As a safe and reliable visualization agent, GNPs can track drugs and accurately indicate the location and boundaries of cancer, opening up new possibilities for cancer treatment. In addition, GNPs have been used in photodynamic therapy to deliver photosensitizers, as well as in combination with photothermal therapy. Therefore, GNPs can be used as a safe and effective nanomaterial in the treatment and diagnosis of gastrointestinal cancer.
Highlights
According to the “2020 Global Cancer Report” recently released by the World Health Organization’s International Agency for Research on Cancer (IARC), the top ten new cancer cases in China in 2020 are as follows: lung, colorectal, gastric, breast, liver, esophageal, thyroid, pancreatic, prostate, and cervical cancers (WHO/IARC published the World Cancer Report 2020)
This review focuses on the application of Gold nanoparticles (GNPs) in gastrointestinal cancer
A monoclonal antibody to HSP70 conjugated to GNPs was able to target mouse colon cancer cells and act as a computed tomography (CT) contrast agent, displaying remarkable imaging ability in spectral CT and high sensitivity for the detection of even single cells [72].The Ac-PEAuNPs was developed with favorable biocompability and remarkable X-ray attenuation property, which can accumulate in normal liver than in necrosis region caused by hepatocellular carcinoma (HCC)
Summary
According to the “2020 Global Cancer Report” recently released by the World Health Organization’s International Agency for Research on Cancer (IARC), the top ten new cancer cases in China in 2020 are as follows: lung, colorectal, gastric, breast, liver, esophageal, thyroid, pancreatic, prostate, and cervical cancers (WHO/IARC published the World Cancer Report 2020). A monoclonal antibody to HSP70 conjugated to GNPs was able to target mouse colon cancer cells and act as a CT contrast agent, displaying remarkable imaging ability in spectral CT and high sensitivity for the detection of even single cells [72].The Ac-PEAuNPs was developed with favorable biocompability and remarkable X-ray attenuation property, which can accumulate in normal liver than in necrosis region caused by HCC. It can serve as a negative CT imaging agent that provide a novel diagnostic method for HCC [73]. Induce cell apoptosis, enhance the level of SOSG
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
