Abstract
In order to study the application value of spiral CT lung density measurement software in the diagnosis of radioactive lung injury, the average CT values of lung apex, hilum, and diaphragm were measured by Pulmo automatic evaluation software of 16-slice spiral CT in 96 patients with different types of radiation lung injury diagnosed by conventional CT and 80 healthy subjects. The radiation lung injury on CT slices was classified, and the lung density was measured. In 96 patients with different types of radiation lung injury, 56 patients had different degrees of increase in average lung density, which was most obvious in the type of air insufficiency and chronic fibrosis. CT values of lung density in the ground glass stage and patch stage of acute radiation pneumonia had little influence due to the range and time of exposure. The lung density of 35 patients with radiation injury was measured in the normal range. There was a significant difference between normal lung density and abnormal lung density in different types of radiation lung injury (X2 = 56.718, P < 0.001). The mean lung density of 68 cases was normal and that of 12 cases was abnormal. There was a significant difference in lung density between the lung injury group and the normal group (X2 = 18.027, P < 0.001). Spiral CT lung density measurement can accurately evaluate the lung density values of different types of radiation lung injury and judge the correlation between lung density and different types of radiation lung injury. It is of great value to diagnose, locate, and master the radiation dose of different types of radiation lung injury.
Highlights
Radiation-induced lung toxicity (RILT) includes early lung injury and late lung injury; early lung injury is called acute radiation pneumonia, occuring within 3 months after the start of radiotherapy; radiation lung injury after 3 months of radiotherapy is called advanced radiation lung injury, and late injury generally refers to radiation pulmonary fibrosis. e cause of radiation lung injury is clear; it is mainly caused by a certain volume of lung tissue receiving a certain dose of ionizing radiation [1]
Studies have shown that Fang et al said that pulmonary interstitial lesions are pulmonary capillary vasculitis, when inflammation is limited to capillary endothelial cells; it can cause mild pulmonary interstitial changes, when epithelial cells are involved; it can cause acute alveolitis, when alveolitis is absorbed; it returns to chronic interstitial inflammation of the lung, if improperly treated or untreated; it causes pulmonary fibrosis [4]. e exact mechanism of CTD with ILL is unknown, may be related to vasculitis, immune complexes in the blood vessel wall activate complement to release neutrophil chemokines, causes neutrophils to gather locally to release collagenase and free
Emphysema is a common disease among chronic respiratory diseases, which is mostly caused by repeated bronchial asthma and chronic bronchitis, resulting in overinflating of the lungs and partial expansion of the distal end of the terminal bronchioles and the damage of lung function with the destruction of lung tissue
Summary
Radiation-induced lung toxicity (RILT) includes early lung injury and late lung injury; early lung injury is called acute radiation pneumonia, occuring within 3 months after the start of radiotherapy; radiation lung injury after 3 months of radiotherapy is called advanced radiation lung injury, and late injury generally refers to radiation pulmonary fibrosis. e cause of radiation lung injury is clear; it is mainly caused by a certain volume of lung tissue receiving a certain dose of ionizing radiation [1]. In the radiotherapy of lung cancer, esophageal cancer, and other chest tumors, after a certain volume of normal lung tissue is irradiated with a certain dose, damaging normal lung tissue, acute radiation pneumonia can occur when such radiation damage to the lung reaches a certain level, manifested as low-grade fever, cough, and chest tightness; severe cases can be manifested as dyspnea, chest pain, and persistent dry cough, if acute radiation pneumonia is not timely intervention and treatment; it can further progress to radiofibrosis of the lung, leading to severe damage to lung function and even death of patients [2]. Jayakrishnan et al believed that KPS score
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