Abstract

Objective To explore the value of contrast enhanced ultrasound (CEUS) for detection of renal microvascular blood perfusion in diabetic nephropathies (DN) rabbits. Methods Twenty rabbits were randomly divided into control group (n=10) and DN model building group (n=10) according to the random number table method. After successful modeling, there were 6 rabbits in DN group and 9 rabbits in control group. Real-time and low acoustic power imaging of the renal cortex was performed using CEUS with SonoVue to observe renal microcirculation. The time intensity curve (TIC) was used to obtain quantitative parameters including time to peak (TTP), peak intensity (PI), mean transit time (MTT), area under the curve (AUC) and so on. Renal function and morphology were also compared. Independent t-test was used to analyze measurement data. Results TIC revealed the TTP[(31.91±6.21)s, (22.30±8.05)s] and MTT[(58.68±9.82)s, (53.37±4.47)s] were longer in DN group than those in control group, with significant differences (t=6.66, 3.80, all P 0.05], slope coefficient during wash-in (0.41±0.08, 0.37±0.06, t=1.26, P>0.05), slope coefficient during wash-out (0.02±0.01, 0.02±0.01, t=0.26, P>0.05) in both DN and control group. Conclusions CEUS may be useful for the early diagnosis of DN. TTP, MTT and PI may be useful quantitative parameters. Key words: Diabetic nephropathies; Contrast enhanced ultrasound; Rabbit; Quantitative analysis

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.