Abstract
The Forsen-Hoffman spin-saturation method of relating exchange rates to the spin-lattice relaxation time, T 1, has been applied to the 13C spectrum of N,N-dimethylformamide. The rate of methyl group exchange can be determined for a two-site exchange problem by measuring the size of the signal at one site in the absence and presence of a strong radiofrequency magnetic field at the second site, provided that T 1 can be measured. In the case of N,N-dimethylformamide, where T 1 values for the two methyl groups are markedly different, T 1 cannot be measured by the conventional (T d−π−t− π 2 ) n pulse sequence when exchange is occurring. However, T 1 for one site can be readily calculated from an “apparent” T 1 which is measured by the (T d−π−t− π 2 ) n pulse sequence in the presence of a strong radiofrequency magnetic field at the second site.
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