Abstract

目的 探讨经双鼻孔鼻蝶入路神经内镜手术在颅底脊索瘤切除中的应用价值。 方法 回顾性分析2015年1月—2016年4月华中科技大学同济医学院附属协和医院神经外科5例颅底脊索患者的临床资料。其中男1例、女4例,年龄44~63岁,均采用经双鼻孔鼻蝶入路神经内镜手术治疗。术前根据影像学图像判断肿瘤位置及其侵润范围,术中用吸引器探查肿瘤的质地,根据术中观察及术后影像学检查判断肿瘤切除程度。 结果 5例患者肿瘤均位于颅底中线区域,侵润范围:向左为13.07~32.34 mm,向右为10.60~37.23 mm,上下为28.15~55.15 mm。术中见肿瘤质地韧,与周围组织粘连紧密,需要内镜显示及2个器械同时操作才能完成切除。本组患者肿瘤全切除3例、次全切除2例;术后病理诊断均为脊索瘤。术后5例患者随访6~20个月,患者症状较术前均有改善,无脑脊液鼻漏、尿崩症、电解质紊乱和死亡的发生,未见肿瘤复发。 结论 采用双鼻孔神经内镜技术,可以利用多器械的协同操作切除较大范围的颅底病变,对于切除颅底脊索瘤是一种较好的手术入路选择。

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