Abstract
Antitumor therapy using a combination of drugs has shown increased clinical efficacy. Active constituents derived from plants can offer several advantages, such as high efficiacy, low toxicity, extensive effects, and multiple targets. At present, the combination of plants' active constituents and chemotherapeutic drugs has attracted increased attention. Nanodrug delivery systems (NDDSs) have been widely used in tumor-targeted therapy because of their efficacy of delivering antitumor drugs. The in vivo process of tumor-targeted NDDSs has several steps. They include blood circulation, tumor accumulation and penetration, target cell internalization and uptake, and drug release and drug response. In each step, NDDSs encounter multiple barriers that prevent their effective delivery to target sites. Studies have been performed to find alternative strategies to overcome these barriers. We reviewed the recent progress of codelivery of active constituents of plants and chemotherapeutics using NDDSs. Progress into transversing the physiological barriers for more effective in vivo antitumor delivery will be discussed in this review.
Highlights
Cancer is one of the most deadly diseases that endangers human health
Nanodrug delivery systems (NDDSs) have demonstrated potential advantages for cancer therapy. e most common carriers of NDDSs include liposomes, nanoparticles, micelles, and polymers. ey can effectively increase the duration of drugs in systemic circulation, improve pharmacokinetics, and promote drug tumor targeting and tumor accumulation
Intravenous administration of NDDSs results in a series of complex in BioMed Research International vivo delivery processes, which includes blood circulation, tumor targeting, tumor accumulation, tumor tissue penetration, tumor cell internalization, and intracellular transport
Summary
Cancer is one of the most deadly diseases that endangers human health. Chemotherapy is currently the major treatment strategy for treating cancers and preventing postsurgical recurrence. Multidrug resistance (MDR) in tumor cells and serious adverse effects have hindered chemotherapy [1] To address these issues, studies have been performed to investigate the effects of drug combinations for cancer treatment. Is reduces efficacy while increasing adverse reactions due to nonspecific targeting of healthy tissue To solve this problem, several strategies have been developed. Ey can effectively increase the duration of drugs in systemic circulation, improve pharmacokinetics, and promote drug tumor targeting and tumor accumulation. Intravenous administration of NDDSs results in a series of complex in BioMed Research International vivo delivery processes, which includes blood circulation, tumor targeting, tumor accumulation, tumor tissue penetration, tumor cell internalization, and intracellular transport. In order to improve drug efficacy and reduce adverse reactions of NDDSs, researchers have developed several exceptional delivery strategies to overcome these barriers. Tumor tissues have several physiological features that include high interstitial fluid pressure, specific enzymes, and oxidative stress [22]
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