Abstract
Malignancies threaten human health seriously. Recently studies show that intercellular signal transduction influences the biological characteristics of tumor cells. It has closely relationship with tumor growth and metastasis. Insulin-like growth factor (IGFs) signal transduction system is a potential mitogen that distributed in the body's tissues, organs and blood. Researches show that the abnormal expression of IGFs exists in many tissues, such as breast cancer, colorectal cancer, gastric carcinoma, lung carcinoma, pancreatic cancer and so on, which may play an important role in occurrence and metastasis as a novel tumor marker.(Chin J Lab Med, 2016, 39: 575-577) Key words: Neoplasms; Somatomedins; Signal transduction; Tumor markers, biological
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