Abstract
The aim of this work was to optimize a GFC method for the analysis of bioactive metal (Cu, Co and Fe) complexes with olygosaccharides (dextran and pullulan). Bioactive metal complexes with olygosaccharides were synthesized by original procedure. GFC was used to study the molecular weight distribution, polymerization degree of oligosaccharides and bioactive metal complexes. The metal bounding in complexes depends on the ligand polymerization degree and the presence of OH groups in coordinative sphere of the central metal ion. The interaction between oligosaccharide and metal ions are very important in veterinary medicine, agriculture, pharmacy and medicine.
Highlights
Stoga je cilj ovog rada izbor i optimizacija odgovarajuće gel filtracione hromatografije (GFC) analitičke metode za analizu oligosaharida u bioaktivnim kompleksima
GFC chromatograms of Cu(II)–pullulan complexes synthesized at different pH values in the range from 7.5 to 12
The interaction between oligosaccharide and metal ions are very important in veterinary medicine, agriculture, pharmacy and medicine
Summary
PRIMENA HP–GFC HROMATOGRAFSKE METODE ZA ANALIZU OLIGOSAHARIDA U BIOAKTIVNIM KOMPLEKSIMA. Iz grupe preparata mikroelemenata neophodnih organizmu, ispitivani su originalno sintetizovani bioaktivni kompleksi na bazi različitih metala (Cu, Fe i Co) sa oligosaharidima dekstrana i pululana. GFC metoda je primenjena za praćenje raspodele molarnih masa, kao i stepena polimerizacije oligosharida dekstrana i pululana, kako polazne supstance u sintezi, tako i u uzorcima različitih bioaktivnih kompleksa mikroelemenata. U literaturi su dobro proučena i druga kompleksna jedinjenja dekstrana sa različitim katjonima: Tb, Al, Cd, Pt, Pb, Ni i Mn. Međutim, kako ishod sinteze, stabilnost i farmakobiološki učinak bioaktivnih kompleksa različitih metala sa oligosaharidima u velikoj meri zavise od stepena polimerizacije primenjenog liganda (oligosaharida) i raspodele molarnih masa kao osnovne karakteristike ponašanja polimerne supstance, javila se potreba za razvojem metoda njihove analize. Stoga je cilj ovog rada izbor i optimizacija odgovarajuće GFC analitičke metode za analizu oligosaharida u bioaktivnim kompleksima
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