Abstract
The pH s values for reference buffer solutions in aqueous acetonitrile, methanol, and tetrahydrofuran mixtures used as mobile phases in LC were subjected to factor analysis in order to discover the number of factors which affect the variation with the percentage of organic co-solvent of the whole data sets. Afterwards, target factor analysis was used to identify these factors. The pH s values were correlated with the solvatochromic parameters (π*, α, β, and E T) of the hydro-organic mixtures according to the results obtained using these chemometric techniques. An equation is proposed which permits the calculation of pH s values in any aqueous acetonitrile, methanol, or tetrahydrofuran mixtures, and thus accurate pH measurements can be made in these media as well as in water. An overview of the effects on pH s values of preferential solvation in these media is also presented.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
