Abstract

Objective To discuss the application of cerebral blood volume software in assessing thecerebral blood volume (CBV) comparative study on the clinical manifestations before and after balloon occlusion test with hypotension.Aiming to find an objective indicator for balloon occlusion test with hypotensionwhich is the gold standard of occluding internal carotid artery (ICA).Methods 10 patients diagnosed with cerebrovascular disease through digital subtraction angiography (DSA) whounderwent balloon occlusion test (BOT) with hypotension from October 2012 to October 2013,including8 cases of carotid cavernous sinus (CCF),1 case of Giant aneurysm on ICA cavernous sinus segment,and 1 case of CCF and pseudoaneurysm.CBV maps were acquiredinSoftware Cerebral Blood Volumeby manual injection of 60 ml CM (370 g/L) before and after balloon occlusion test with hypotension within 15 minutes,from which mean relative CBV (rCBV) of regions of interest (ROIs) was comparedin the same axial view,The change of mean rCBV was compared with the change of clinical manifestations before and after Ballon Occlusion Test with hypotension.Results There were 10 patients were involved inthis study,of which,no ischemic complicationswere recognized in 8 patients.Good perfusion symmetry was detected with averaged rCBV 1.02 ± 0.06.in those 8 patients,1 patient underwent permanent ICA occlusion with a detachable balloonwithout acute or delayed neurologic deficit perceived.The others underwent nidus embolization with coils with keeping ICAunobstructed and got well recovered.Two patients failed to tolerate the BOT testwith hypotensionwho developed in disturbance of consciousness and the contralateral limb hemiplegia.CBVs from the affected hemisphere was significantly lower than those from the unaffected hemisphere in the corresponding regions with mean rCBV reduction close to 24% and 21%.2 patients underwent nidus embolization with coils with keeping ICA unobstructed and got well recovered.Conclusion CBV maps have a good consistency with clinical manifestationsbefore and after balloonocclusion testwith hypotension.It can be an objective indicator for the gold standard of occluding ICA. Key words: Cerebral blood volume software; Cerebral blood volume; Balloon occlusion test with hypotension; Carotid-cavernous sinus

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