Abstract
Different types of microcrystalline and microfine celluloses are often used in direct tabletting mixtures. An evaluation has been undertaken of the connection between the pharmaceutical behaviour of a range of the cellulose products and the powder and tablet properties of the tabletting mixtures, using the multivariate statistical technique of canonical analysis. The cellulose properties were reflected in the behaviour of the tabletting mixtures, in particular the bulk volume, the particle size range, the formation energy (force-displacement-curves, E 2) and the elastic recovery energy ( E 3). The approach demonstrated that an exchange of the cellulose product in direct tabletting mixtures is only possible in special cases.
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