Abstract
Atomic force microscopy (AFM)-based single molecule force spectroscopy (SMFS) is one of the most useful methods in the investigation of intra- or intermolecular interactions. To simplify the sample system and the data analysis, real biological and material systems have usually been simplified, and the target molecule of interest is normally extracted and bridged between the AFM tip and substrate for study, which is an effective way of understanding the real systems. With the development of technology (including the improvement of sample immobilization method), it is possible now to directly investigate molecular interactions in living system and real materials. The information obtained will be more useful for the better control of relevant biological processes and the design of high performance polymer materials. In this paper, recent progresses in AFM-SMFS study of molecular interactions in living cells and polymer materials are reviewed.
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