Abstract
The applicability of interphase chromosome-specific multicolor banding (ICS-MCB) for studying neurodevelopmental and neurodegenerative disorders
Highlights
Neurodevelopmental and neurodegenerative disorders have been systematically associated with genomic variations [1,2,3,4]
Since the overwhelming majority of human cells are likely to be in interphase, Interphase chromosome-specific multicolor banding (ICS-MCB) represents an important tool for chromosomal and genomic research
No conflict of interest was recorded with respect to this article
Summary
Neurodevelopmental and neurodegenerative disorders have been systematically associated with genomic variations (i.e. chromosome abnormalities, copy number variations and single-gene mutations) [1,2,3,4]. The most important molecular cytogenetic technique for studying chromosomes in individual cells is interphase fluorescence in situ hybridization (FISH) [10]. The latter has been already shown to provide valuable data on chromosomal mosaicism and the contribution to brain pathology in neurodevelopmental and neurodegenerative disorders [7, 11, 12]. The present communication pays attention to a FISH-based technique for studying individual interphase chromosomes in their integrity in single cells – interphase chromosome-specific multicolor banding (ICS-MCB) – and to the applicability for studying neurodevelopmental and neurodegenerative disorders.
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