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Abstract
Background & objectives: Resveratrol (trans-3,4,5’ –trihydroxystilbene) is an active compound in food, such as redgrapes, peanuts, and berries. A body of evidence shows that resveratrol is able to inhibit thegrowth of many cancers such as leukemia, breast cancer and primary brain tumors. The objective of the present study was to demonstrate the dose and time dependent apoptotic effect of Resveratrol on Human Caski cell line.
 Methods: We used cell viability assays like MTT and Trypan blue assays to demonstrate the inhibition of cancer cell proliferation in a dose and time dependent manner.
 Results: Our results have shown that Resveratrol inhibited proliferation of Caski cells in a concentration and time dependent manner in 48 hr cultures. No significant effect was observed in 24 hour cultures of cell viability assays.
 Interpretation & conclusions: The results indicated that Resveratrol and NAC inhibited cell growth in Caski cells as a function of dose and time.
 Keywords: Resveratrol , Cervical cancer, apoptosis
Highlights
Cervical cancer lesions are a major threat to the health of women and represents the second most common cancer worldwide amongst women
Our results have shown that Resveratrol inhibited proliferation of Caski cells in a concentration and time dependent manner in 48 hr cultures
Interpretation & conclusions: The results indicated that Resveratrol and NAC inhibited cell growth in Caski cells as a function of dose and time
Summary
Cervical cancer lesions are a major threat to the health of women and represents the second most common cancer worldwide amongst women. Cervical cancer is the third largest cause of cancer mortality in India after cancers of the mouth & oropharynx, and oesophagus, accounting for nearly 10% of all cancer related deaths in the country[1] Among women, it is the leading cause of cancer mortality, accounting for 26% of all cancer deaths[2,3,4].New approaches to prevention and therapy for cancer including enhancement of natural killer cells,anti-angiogenic process,antioxidant defence systems and direct cytotoxicity against cancer cells without harming the normal cells are urgently needed[5]. The chemical formula of resveratrol is 3,5,4 –trihydroxystilbene and the natural sources are red wine,grapes, nuts,mulberries etc.Resveratrol is a potent antioxidant[8] It can inhibit cellular events associated with tumor initiation, promotion, and progression[9]. Resveratrol provides a number of anti-aging health benefits including improved metabolism, cardioprotection,and cancer prevention[10]
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