The anxiolytic effect of some plant extracts in clinical trials and animal models

Malkhaz Makashvili Malkhaz Makashvili,Nino Akhobadze Nino Akhobadze,Ketevan Gogeshvili Ketevan Gogeshvili,Giorgi Andronikashvili Giorgi Andronikashvili,Tea Gurashvili Tea Gurashvili,Tamila Bagashvili Tamila Bagashvili,Tamar Nadiradze Tamar Nadiradze

doi:10.30574/wjbphs.2021.5.3.0023

Malkhaz Makashvili Malkhaz Makashvili, Nino Akhobadze Nino Akhobadze + Show 5 more

Open Access

https://doi.org/10.30574/wjbphs.2021.5.3.0023

Copy DOI

Abstract

The phenomenon of anxiety remains poorly understood and there is much to be learnt about its’s effective treatment. Here we discuss the data of available scientific literature concerning the use of plant derived extracts in the treatment of anxiety. Study of the treating effects of natural alternatives to prescription drugs is very important in regard to limitations of current drug therapies. Significance of the study of treating efficacy of endemic plant species, endemic to Georgia in particular, and the use of animal models, such as rat grooming and rat behavior in maze, for evaluation of the anxiolytic efficacy of phytomedicines is discussed as well. We conclude, that medical as well as experimental trials in animal models of anxiety provide strong argument for the use of plant extracts as an alternative to the current drug therapies for anxiety.

Highlights

Stress-induced anxiety, as a consequence of the impact of stressogenic environment on living things, remains poorly understood and there is much to be learnt about its’s effective treatment
We discuss the data of available scientific literature concerning the use of plant derived extracts in the treatment of anxiety
We reported on anxiolytic effect of the tincture of Melissa officinalis in rats, exposed to the bright light as compared to the control group, not treated with the tincture [41]

Summary

Introduction

Stress-induced anxiety, as a consequence of the impact of stressogenic environment on living things, remains poorly understood and there is much to be learnt about its’s effective treatment. We discuss the data of available scientific literature concerning the use of plant derived extracts in the treatment of anxiety. Significance of the study of treating efficacy of endemic plant species, endemic to Georgia in particular, and the use of animal models, such as rat grooming and rat behavior in maze, for evaluation of the anxiolytic efficacy of phytomedicines is discussed as well.

Results

Conclusion