Abstract
The antiviral immune forces awaken in the cancer wars.
Highlights
Viruses are the most abundant microorganisms on earth, and it is estimated that there are at least 10 times more viruses than bacteria in the human microbiome [1]
Many viruses can permanently settle in a host cell, are minimally influenced by environmental changes, and can even be inherited when infecting germline cells
When suppressed viral gene expression in a tumor is reactivated from the virome, they are recognized as tumor neoantigens by host immune systems [6, 11]
Summary
Citation: Pyeon D, Vu L, Giacobbi NS, Westrich JA (2020) The antiviral immune forces awaken in the cancer wars. PLoS Pathog 16(9): e1008814. https://doi.org/10.1371/journal.ppat.1008814 Funding: The research of the Pyeon laboratory is supported by the NIH grants R01 DE026125 and R01 DE029524, and MSU Global Impact Initiative. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Competing interests: The authors have declared that no competing interests exist.
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