Abstract
(Cell Host & Microbe 13, 452–464; April 17, 2013) In Figure 2A of the above paper, the VECTOR panel was duplicated during the arrangement of the figure panels. Please refer to the corrected, revised figure (Figure 2). We regret any inconvenience this has caused. The Antiviral Effector IFITM3 Disrupts Intracellular Cholesterol Homeostasis to Block Viral EntryAmini-Bavil-Olyaee et al.Cell Host & MicrobeApril 17, 2013In BriefVesicle-membrane-protein-associated protein A (VAPA) and oxysterol-binding protein (OSBP) regulate intracellular cholesterol homeostasis, which is required for many virus infections. During entry, viruses or virus-containing vesicles can fuse with endosomal membranes to mediate the cytosolic release of virions, and alterations in endosomal cholesterol can inhibit this invasion step. We show that the antiviral effector protein interferon-inducible transmembrane protein 3 (IFITM3) interacts with VAPA and prevents its association with OSBP, thereby disrupting intracellular cholesterol homeostasis and inhibiting viral entry. Full-Text PDF Open Archive
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